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essentially minimizes overlap between populations. It is important to distinguish between a modeling process and a partitioning process. When data are partitioned via regions and gates, boundaries are created separating one type of particle from another. Each channel contains either one type of particle or another. In modeling, the categorization is done on probabilistic grounds. A single channel can have one, two, or more different types of particles. The most successful use of these models has been in DNA analysis, for two probable reasons: the very tight regulation cells have on the total amount of DNA present yields a very precise and interpretable unbroadened function, and a fairly firm understanding of the mechanics of cell division and published data indicate the prognostic importance of some DNA model parameters.

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