Chemotherapy for Advanced Resectable Disease

Although the success of chemotherapy in unresectable disease has been modest, encouraging results have been achieved in the setting of locally advanced primary disease. Although the primary goal of cancer therapy remains cure or prolonged survival, an important secondary goal of the use of chemotherapy is the reduction of the morbidity of treatment. In the head and neck, this takes the form of preservation of the organs of speech and swallowing. Three general approaches have been used, alone or in combination: induction therapy, adjuvant therapy, or chemotherapy concomitant with primary radiation.

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