Several controversies surround the use of END in the treatment of HNSCC. Included are the therapeutic effects of selective procedures and the indications for adjuvant therapies. Ongoing studies are attempting to define the role of SND for the treatment of limited cervical disease. END remains the most accurate tool currently available to stage the neck in HNSCC. Staging provides important prognostic information and targets patients who may benefit from combination therapy.
Pitman and Johnson—CHAPTER 1
1. Baredes S, Leeman DJ, Chen TS, et al. Significance of tumor thickness in soft palate carcinoma. Laryngoscope 1993;103: 389-393
2. Fukano H, Matsuura H, Hasegawa, et al. Depth of invasion as a predictive factor for cervical lymph node metastasis in tongue carcinoma. Head Neck 1997;19:205-210
3. Fagan JJ, Collins B, Barnes L, et al. Perineural invasion in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 1998;124:637-640
4. Takes, RP, Baatenburg de Jong RJ, Schuuring E, et al. Markers for assessment of nodal metastasis in laryngeal carcinoma. Arch Otolaryngol Head Neck Surg 1997;123:412-418
5. Wolf GT, Fisher SG, Truelson JM, et al. DNA content and regional metastases in patients with advanced laryngeal squa-mous carcinoma. Laryngoscope 1994;104:479-483
6. American Joint Committee on Cancer. Manual for staging of cancer. 4th ed. Philadelphia: JB Lippincott, 1992
7. Friedman M, Roberts N, Kirshebaum G, et al. Nodal size of metastatic squamous cell carcinoma of the neck. Laryngoscope 1993;103:854-856
8. Moreau P, Goffart Y, Collignon J. Computed tomography of metastatic cervical lymph nodes. Arch Otolaryngol Head Neck Surg 1990;116:1190-1193
9. Don DM, Anzai Y, Lufkin RB, et al. Evaluation of cervical lymph node metastases in squamous cell carcinoma of the head and neck. Laryngoscope 1995;105:669-674
10. Byers RM, El-Naggar AK, Lee Y, et al. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue. Head Neck 1998;20: 138-144
11. Dinardo LJ. Lymphatics of the submandibular space: an anatomic, clinical and pathologic study with applications to floor-of-mouth carcinoma. Laryngoscope 1998;108:206-214
12. van den Brekel MWM, van der Waal I, Meijer CJLM, et al. The incidence of micro metastases in neck dissection specimens obtained from elective neck dissections. Laryngoscope 1996;106:987-991
13. Woolgar JA. Carcinoma of the tongue: pathological consideration in management of the neck. J R Soc Med 1996; 89:611-615
14 Schuller DE, Bier-Lanning CM, Sharma PK, et al. Tissue-conserving surgery for prognosis, treatment, and function preservation. Laryngoscope 1998;108:1599-1604
15. Ogura JH, Biller HF, Wette R. Elective neck dissection for pharyngeal and laryngeal cancers. Ann Otol 1971;80:646-651
16. Lee JG, Krause CJ. Radical neck dissection: elective, therapeutic, and secondary. Arch Otolaryngol 1975;101:656-659.
17. McGuirt WF Jr, Johnson JT, Myers EN, et al. Floor of mouth carcinoma in management of the clinically negative neck. Arch Otolaryngol Head Neck Surg 1995;121:278-282
18. Yuen APW, Wei WI, Wong YM, et al. Elective neck dissection versus observation in the treatment of early oral tongue carcinoma. Head Neck 1997;19:583-588, Ann Otolaryngol 1980;89:578-581
19. Fletcher GH. Elective irradiation of subclinical disease in cancers of the head and neck. Cancer 1972;29:1450-1454
20. Mendenhall WM, Million RR. Elective irradiation for squa-mous cell carcinoma of the head and neck: analysis of dose related factors and causes of failure. Int J Radiat Oncol Biol Phys 1986;12:751
21. Bocca E, Pignataro O, Oldini C, Cappa C. Functional neck dissection: an evaluation and review of 843 cases. Laryngoscope 1984;94:942-945
22. Molinari R, Cantu G, Chiesa F, Grandi C. Retrospective comparison of conservative and radical neck dissection in laryn-geal cancer. Ann Otol Rhinol Laryngol 1989;1980:578-581
23. Byers RM, Wolf PF, Ballantyne AJ. Rationale for elective modified neck dissection. Head Neck Surg 1988;10:160-167
24. Pitman KT, Johnson JT, Myers EN. Effectiveness of selective neck dissection for management of the clinical negative neck. Arch Otolaryngol Head Neck Surg 1997;123:917-922
25. Seydel HG. The risk of tumor induction in man following medical irradiation for malignant neoplasm. Cancer 1975; 35:1641-1645
26. van der Laan BF, Baris G, Gregor RT, et al. Oncology in focus: radiation-induced tumours of the head and neck. J Laryngol Otol 1995;109:346-349
27. Fakih AR, Rao RS, Patel AR. Prophylactic neck dissection in squamous cell carcinoma of oral tongue: a prospective randomized study. Semin Surg Oncol 1989;5:327-330
28. Vandenbrouck C, Sancho-Garnier H, Chassagen D, et al. Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity. Cancer 1980;46: 386-390
29. Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg 1990;160:405-409
30. Alvi A, Johnson JT. Extracapsular spread in the clinically negative neck (N0): implications and outcome. Otolaryngol Head Neck Surg 1996;114:65-70
31. Spiro RH, Morgan GJ, Strong EW, et al. Supraomohyoid neck dissection. Am J Surg 1996;172:650-653
32. Medina J, Byers RM. Supraomohyoid neck dissection: rationale, indications and surgical technique. Head Neck 1989;11:111-112
33. Spiro RH, Gallo O, Shah JP. The jugular node dissection in patients with squamous carcinoma of the larynx or pharynx. Am J Surg 1993;166:399-402
34. Spiro JD, Spiro RH, Shah JP, Sesions RB, Strong EW. Critical assessment of supraomohyoid neck dissection. Am J Surg 1988;156:286-289
35. Byers RM, Weber RS, Andrews T, et al. Frequency and therapeutic implications of "skip metastases" in the neck from squamous carcinoma of the oral tongue. Head Neck 1997;19: 14-19
The choice of treatment of the neck in patients with cancer of the head and neck has been controversial for decades. In recent years, the focus of that controversy has shifted. The radical neck dissection is no longer the only operation performed when treatment of the neck nodes is necessary. In fact, today, it is the least commonly done type of neck dissection. Currently, one of the greatest controversies centers around the role of the selective neck dissections in the treatment of the NO neck. Interestingly, alongside the decision to perform a selective neck dissection are a number of controversial issues regarding alternative, less invasive methods of staging the cervical lymph nodes, which include imaging studies. The discussion that follows addresses these controversies and analyzes the efficacy of the selective neck dissections.
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