Elevated Eosinophil and Basophil Counts

In accordance with their physiological role, an increase in eosinophils (> 400/^1, i.e. for a leukocyte count of 6000, more than 8% in the differential blood analysis) is usually due to parasitic attack (p. 5). In the Western hemisphere, parasitic infestations are investigated on the basis of stool samples and serology.

Strongyloides stercoralis in particular causes strong, sometimes extreme, elevation of eosinophils (may be up to 50%). However, eosinophilia of variable degree is also seen in ameba infection, in lambliasis (giardiasis), schistosomiasis, filariasis, and even malaria.

Bacterial and viral infections are both unlikely ever to lead to eosinophilia except in a few patients with scarlet fever, mononucleosis, or infectious lymphocytosis. The second most common group of causes of eosinophilia are allergic conditions: these include asthma, hay fever, and various dermatoses (urticaria, psoriasis). This second group also includes drug-induced hypersensitivity with its almost infinitely multifarious triggers, among which various antibiotics, gold preparations, hydantoin derivatives, phenothiazines, and dextrans appear to be the most prevalent. Eosinophilia is also seen in autoimmune diseases, especially in scleroderma and panarteritis. All neoplasias can lead to "paraneoplastic" eosinophilia, and in Hodgkin's disease it appears to play a special role in the pathology, although it is nevertheless not always present.

A specific hypereosinophilia syndrome with extreme values (usually > 40%) is seen clinically in association with various combinations of splenomegaly, heart defects, and pulmonary infiltration (Loeffler syndrome), and is classified somewhere between autoimmune diseases and myeloproliferative syndromes. Of the leukemias, CML usually manifests moderate eosinophilia in addition to its other typical criteria (see p. 114). When moderate eosinophilia dominates the hematological picture, the term chronic eosinophilic leukemia is used. Acute, absolute predominance of eosinophil blasts with concomitant decrease in neutrophils, erythro-cytes, and thrombocytes suggests the possibility of the very rare acute eosinophilic leukemia.

Elevated Basophil Counts. Elevation of segmented basophils to more than 2-3% or 150/^1 is rare and, in accordance with their physiological role in the immune system regulation, is seen inconsistently in allergic reactions to food, drugs, or parasites (especially filariae and schistosomes), i.e., usually in conditions in which eosinophilia is also seen. Infectious diseases that may show basophilia are tuberculosis and chickenpox; metabolic diseases where basophilia may occur are myxedema and hyperlipidemia. Au-tonomic proliferations of basophils are part of the myeloproliferative a b c

Reactive Bronchial Cells

Fig. 43 Eosinophilia and basophilia. a Screening view of blood cells in reactive eosinophilia: eosinophilic granulocytes (1), segmented neutrophilic granulocyte (2), and monocyte (3) (reaction to bronchial carcinoma). b and cThe image shows an eosinophilic granulocyte (1) and a basophilic granulocyte (2) (clinical osteomyelosclerosis). d Bone marrow in systemic mastocytosis: tissue mast cell (3), which, in contrast to a basophilic granulocyte, has an unlobed nucleus, and the cytoplasm is wide with a tail-like extension. Tissue mast cells contain intensely basophilic granules. 125

Fig. 43 Eosinophilia and basophilia. a Screening view of blood cells in reactive eosinophilia: eosinophilic granulocytes (1), segmented neutrophilic granulocyte (2), and monocyte (3) (reaction to bronchial carcinoma). b and cThe image shows an eosinophilic granulocyte (1) and a basophilic granulocyte (2) (clinical osteomyelosclerosis). d Bone marrow in systemic mastocytosis: tissue mast cell (3), which, in contrast to a basophilic granulocyte, has an unlobed nucleus, and the cytoplasm is wide with a tail-like extension. Tissue mast cells contain intensely basophilic granules. 125

a b d c pathologies and can develop to the extent of being termed "chronic basophilic leukemia." In the very rare acute basophilic leukemia, the cells in the basophilic granulocyte lineage mature in the bone marrow only to the stage of promyelocytes, giving a picture similar to type M3 AML (p. 98).

Being an expression of idiopathic disturbance of bone marrow function, elevated basophil counts are a relatively constant phenomenon in myeloproliferative syndromes (in addition to the specific signs of these diseases), especially in CML. Acute basophilic leukemia is extremely rare; in this condition, some of the dedifferentiated blasts contain more or less ba-sophilic granules.

The tissue-bound analogs of the segmented basophils, the tissue mast cells, can show benign or malignant cell proliferation, including the (extremely rare) acute mast cell leukemia (Table 21).

Table 21 Different forms of benign and malignant proliferation of tissue mast cells

Clinical picture

Clinical diagnosis

Evidence

In childhood, solitary or multiple skin nodules, some brownish

Localized mastocytosis

Histology

1 Sometimes transition

Diffuse brownish papules, with urticaria on irritation

Hyperpigmented spots, papules and/or dermo-graphism; histamine symptoms: flushing, headache, pruritus, abdominal spasms, shock

Malignant transformation, possibly with osteolysis, enlarged lymph nodes, splenomegaly, hepatomegaly

Migration of leukemic cells to peripheral blood

Urticaria pigmentosa

Typical clinical picture

Systemic mastocytosis

Histology

Malignant mastocyto-sis*

Histology

Acute mast cell leukemia

CBC (bone marrow)

* May occur de novo without preceding stages and without skin involvement.

* May occur de novo without preceding stages and without skin involvement.

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Responses

  • mimosa
    Is absolute basophilia seen in cml?
    4 years ago
  • Almaz Negassi
    Are eosinophils and basophils allergic response?
    4 years ago
  • faizan
    What disease can cause your eosinophil,basophil,and neutrophil counts are elevated?
    4 years ago
  • susanne
    What causes elevated monocytes and granulocytes?
    4 years ago
  • RODERIC
    What disease causes your eosinophil, basophil, and neutrophil count to be elevated?
    4 years ago
  • Santo Siciliano
    What happens when esoinophil, basophil and neutrophil counts are elevated?
    4 years ago
  • miranda
    Which is viral eosinophil or basophil?
    4 years ago
  • Coby
    What causes high basophil count?
    3 years ago
  • Fethawit Robel
    What causes elevated eosinophils and basophils?
    3 years ago
  • ted
    What causes Basophil blood cells to be elevated?
    3 years ago
  • karolin
    What causes basophil elevation?
    3 years ago
  • elga pisani
    What causes high basophils and eosinophils?
    3 years ago
  • jonas
    What is the main cause of high neutrophils eosinophils and basophils?
    3 years ago
  • ruaridh
    What is the effect if esnofil count is 6000?
    3 years ago
  • henna
    What causes high eosinpohil and basophil?
    3 years ago
  • rudolph
    What causes high basophil absolute?
    2 years ago
  • Kaarina
    What causes elevation of neutrophils and eosinophils?
    2 years ago
  • cora
    Can exercise cause basophil count to be high?
    2 years ago
  • Oran
    Are my elevated eosinophils caused by leukemia?
    2 years ago
  • nob
    What will be neutrophil, basophil, esonophil cells in malaria?
    2 years ago
  • gary ginn
    What happen if basophil and eosinophil will increase?
    2 years ago
  • Jarno
    What does increased eosinophils and basophils mean?
    2 years ago
  • Ellie-louise Mackenzie
    What causes high basophil and eosinaphil counts?
    2 years ago
  • beth reynolds
    What happen if basophil and eosinophil is high?
    2 years ago
  • patricia
    What causes an increase in basophils?
    2 years ago
  • Olga
    Do other kevels need to be elavated when ensinophils?
    2 years ago
  • Mathias
    What diseases causes high basophil count?
    2 years ago
  • lena
    What causes decrease in eosinophil %?
    2 years ago
  • jonna
    What causes a basophil percentage increase?
    2 years ago
  • semrawit
    What infection causes fatigue and abnormal esonophils?
    2 years ago
  • jessamine
    Does henna increased eosinophil?
    2 years ago
  • violante
    Does basophils abs 0.13 mean mast leukemia?
    2 years ago
  • marcho
    What does basophilia and eosinophilia indicate?
    1 year ago
  • huriyyah
    What conditions can cause high eosinophils and basophils count in leukocytes?
    1 year ago
  • Regina
    What are basophils and eusinophils?
    1 year ago
  • Frans
    What diseases are linked to elevated basophils?
    1 year ago
  • Gebre
    What number of abs basoplil are seen in leukemia?
    1 year ago
  • Ruben
    What causes a rise in basophils?
    1 year ago
  • william
    What leads to high basophils?
    1 year ago
  • Silke
    When easoinphyl and basphyl count increases?
    1 year ago
  • fosco
    Can mesh implants cause high basophils and lymphocytes?
    1 year ago
  • mira
    What might elevated esinophils basophils and neutrophils be?
    1 year ago
  • kane
    What is caused due to increase in meutrophils and eosinophils?
    1 year ago
  • Furuta
    What does raised eosinophils and basophils mean?
    1 year ago
  • Bernd
    What does it mean when your eosinophil, basophil, and neutrophil counts are elovated?
    1 year ago
  • marigold
    Does a low eosphil mean any type of leukemia?
    1 year ago
  • Fulgenzia Barese
    What besophil 150 indicates?
    1 year ago
  • ailie
    What happen when basophils and eosinophils percen?
    1 year ago
  • jordan
    When neutrophil and eusinophil increase then what happen?
    1 year ago
  • Eric Fried
    Why would monocytes eosinophils and basophils be elevated?
    1 year ago
  • bisirat
    What counts as elevation of eosinophil count?
    1 year ago
  • susanna
    WHAT DOES ELEVATED ESONOPHILS REPRESENT?
    1 year ago
  • wolfgang
    What is a basophil count mine is 1% high?
    12 months ago
  • samppa
    What is disease of high eosinophils and basophils?
    11 months ago
  • vilho
    Can elevated basophils cause fever?
    11 months ago
  • Tuomo Hiukka
    What does a elevated eosinophil and monocyte mean?
    11 months ago
  • Bilba
    Why are my monocytes and eosinophils high?
    11 months ago
  • lukas
    Can malaria cause a high granulocyte reading?
    10 months ago
  • aleandro
    What are the conditions in which the eosinophil and neutrophil counts increase in the blood?
    10 months ago
  • miika sutinen
    What happens when lymphocytes basophils n eosinophils count gets low?
    10 months ago
  • Deodato
    What does it mean when your basophil monocyte and eosinophil counts are high?
    10 months ago
  • bernd
    How to increase monocytes and basophil count?
    10 months ago
  • Boris
    What type of eating increase basophils count rising?
    10 months ago
  • julia krause
    Can basophils be elevated in lupus?
    10 months ago
  • Louise Walker
    Do allergies increase basophil count?
    9 months ago
  • terry
    When eosinophils and basophils rise?
    9 months ago
  • amanda
    Why eosinophil count high?
    9 months ago
  • katharina
    HOW ELEVATED ARE THE ESINOPHILS FOR TREATMENT WITH NUCALS?
    8 months ago
  • maximilian
    Does ferritin increase eosinophils?
    8 months ago
  • mebrat brhane
    What are the causes of elevated esosinophil count?
    8 months ago
  • luigia
    What happen if there is low count of basophils and eosinophils in blood?
    8 months ago
  • john
    What do MONOCYTE , EOSINOPHIL, BASOPHIL PERCENTAGEs in bloodwork results mean?
    8 months ago
  • Raymond
    What causes high eosinophil and basophil count?
    7 months ago
  • aaran
    Can the increased percent of eosinophils n decreased percent of basophils leads to infection?
    7 months ago
  • brett luther
    WHEN MONOCYTES AND BASOPHILS ARE HIGH?
    7 months ago
  • kelvin
    Can having a high absolute basophils cause pain?
    6 months ago
  • RUARIDH CAMPBELL
    What would cause a persons basophils to elevate while a white counts returns to normal?
    6 months ago
  • Murray
    Why does basophil are rarely seen?
    6 months ago
  • Eglantine Button
    What causes basophils and esonophils to be high?
    6 months ago
  • richard
    What happens if basophils and monocytes increse?
    6 months ago
  • temshe
    What causes high levels of basophils?
    6 months ago
  • adamo
    What does it mean if monocytes, eosinophils and basophils are high?
    6 months ago
  • henri
    What could be the reason when basophil, esenophil are raised?
    5 months ago
  • daniela
    What is basophils high reading mean?
    5 months ago
  • Clare Donaldson
    How will b high level basophill treated?
    5 months ago
  • David
    Does basophin is increse in malaria?
    5 months ago
  • Leona
    What happens when acidophils count increases in humanbeing?
    5 months ago
  • EOIN
    What happens if esinophil n basophil count increased?
    5 months ago
  • RALF KAISER
    How severe malaria affects esinophils,basophils and neutrophils?
    5 months ago
  • Kelsi
    What will happen if there is no monocytes&basophils in the blood of a four year child?
    5 months ago
  • janina
    What causes slightly high basophil percent on blood work?
    5 months ago
  • mario schiffer
    What cause basophils counts in blood elevated?
    5 months ago
  • Porro
    What indication does monocytes high,eosinophils high,basophil high and neutrophils low portray?
    5 months ago
  • nebay
    Why woyld basophils and eosinophils elevate?
    4 months ago
  • rezene ermias
    How does malaria parasite affect monocyte, eosinophil and basophil?
    4 months ago
  • Lori
    What conditions may present due to high basophil?
    4 months ago
  • falco took-brandybuck
    What is absolute eosinophils?
    4 months ago
  • Tewolde
    What is the absolute eosinophils and eosinphils?
    3 months ago
  • laila wright
    What does it mean if your basophilis count I'd high?
    3 months ago
  • Murray
    Why are my dogs Monocytes, Eosinophils and Basophils high?
    3 months ago
  • Yolanda Bolger-Baggins
    What causesincreased basophil?
    3 months ago
  • frank
    What does the value of Basophil and Esnophil indicate?
    3 months ago
  • david
    What would make basephils decrease?
    3 months ago
  • Futsum
    What do elevated monocytes, esonophils and basophils indicate?
    2 months ago
  • Rudy
    What happen when basophils raise?
    2 months ago
  • donald
    What does a high baso mean in blood test?
    2 months ago
  • phyllis
    When eosophils/ basophils are high?
    2 months ago
  • Spencer Valdez
    When lymphocyte and basophil is increases?
    2 months ago
  • Aurora
    How to increase monocyte and basophil in blood?
    1 month ago
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    How to improve esnophills and basophills?
    1 month ago
  • matthias konig
    What causes basophils to rise above the normal range in the children?
    1 month ago
  • Fikru Mustafa
    What is basophill count in body?
    27 days ago
  • FEDRO
    What does elevated basophils and neutrophils means?
    27 days ago
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    How to increase basophils and monocyte?
    22 days ago
  • sophia m
    What cause increase of basophils and esnophils?
    20 days ago
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    Does lung disease cause basophilia?
    18 days ago
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    What causes high segmented neutrophils?
    18 days ago
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    What is the causes of an increasment of monocyte and esnophils?
    16 days ago
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    What can elevate basophil count?
    14 days ago

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