Elevated Eosinophil and Basophil Counts

In accordance with their physiological role, an increase in eosinophils (> 400/^1, i.e. for a leukocyte count of 6000, more than 8% in the differential blood analysis) is usually due to parasitic attack (p. 5). In the Western hemisphere, parasitic infestations are investigated on the basis of stool samples and serology.

Strongyloides stercoralis in particular causes strong, sometimes extreme, elevation of eosinophils (may be up to 50%). However, eosinophilia of variable degree is also seen in ameba infection, in lambliasis (giardiasis), schistosomiasis, filariasis, and even malaria.

Bacterial and viral infections are both unlikely ever to lead to eosinophilia except in a few patients with scarlet fever, mononucleosis, or infectious lymphocytosis. The second most common group of causes of eosinophilia are allergic conditions: these include asthma, hay fever, and various dermatoses (urticaria, psoriasis). This second group also includes drug-induced hypersensitivity with its almost infinitely multifarious triggers, among which various antibiotics, gold preparations, hydantoin derivatives, phenothiazines, and dextrans appear to be the most prevalent. Eosinophilia is also seen in autoimmune diseases, especially in scleroderma and panarteritis. All neoplasias can lead to "paraneoplastic" eosinophilia, and in Hodgkin's disease it appears to play a special role in the pathology, although it is nevertheless not always present.

A specific hypereosinophilia syndrome with extreme values (usually > 40%) is seen clinically in association with various combinations of splenomegaly, heart defects, and pulmonary infiltration (Loeffler syndrome), and is classified somewhere between autoimmune diseases and myeloproliferative syndromes. Of the leukemias, CML usually manifests moderate eosinophilia in addition to its other typical criteria (see p. 114). When moderate eosinophilia dominates the hematological picture, the term chronic eosinophilic leukemia is used. Acute, absolute predominance of eosinophil blasts with concomitant decrease in neutrophils, erythro-cytes, and thrombocytes suggests the possibility of the very rare acute eosinophilic leukemia.

Elevated Basophil Counts. Elevation of segmented basophils to more than 2-3% or 150/^1 is rare and, in accordance with their physiological role in the immune system regulation, is seen inconsistently in allergic reactions to food, drugs, or parasites (especially filariae and schistosomes), i.e., usually in conditions in which eosinophilia is also seen. Infectious diseases that may show basophilia are tuberculosis and chickenpox; metabolic diseases where basophilia may occur are myxedema and hyperlipidemia. Au-tonomic proliferations of basophils are part of the myeloproliferative a b c

Reactive Bronchial Cells

Fig. 43 Eosinophilia and basophilia. a Screening view of blood cells in reactive eosinophilia: eosinophilic granulocytes (1), segmented neutrophilic granulocyte (2), and monocyte (3) (reaction to bronchial carcinoma). b and cThe image shows an eosinophilic granulocyte (1) and a basophilic granulocyte (2) (clinical osteomyelosclerosis). d Bone marrow in systemic mastocytosis: tissue mast cell (3), which, in contrast to a basophilic granulocyte, has an unlobed nucleus, and the cytoplasm is wide with a tail-like extension. Tissue mast cells contain intensely basophilic granules. 125

Fig. 43 Eosinophilia and basophilia. a Screening view of blood cells in reactive eosinophilia: eosinophilic granulocytes (1), segmented neutrophilic granulocyte (2), and monocyte (3) (reaction to bronchial carcinoma). b and cThe image shows an eosinophilic granulocyte (1) and a basophilic granulocyte (2) (clinical osteomyelosclerosis). d Bone marrow in systemic mastocytosis: tissue mast cell (3), which, in contrast to a basophilic granulocyte, has an unlobed nucleus, and the cytoplasm is wide with a tail-like extension. Tissue mast cells contain intensely basophilic granules. 125

a b d c pathologies and can develop to the extent of being termed "chronic basophilic leukemia." In the very rare acute basophilic leukemia, the cells in the basophilic granulocyte lineage mature in the bone marrow only to the stage of promyelocytes, giving a picture similar to type M3 AML (p. 98).

Being an expression of idiopathic disturbance of bone marrow function, elevated basophil counts are a relatively constant phenomenon in myeloproliferative syndromes (in addition to the specific signs of these diseases), especially in CML. Acute basophilic leukemia is extremely rare; in this condition, some of the dedifferentiated blasts contain more or less ba-sophilic granules.

The tissue-bound analogs of the segmented basophils, the tissue mast cells, can show benign or malignant cell proliferation, including the (extremely rare) acute mast cell leukemia (Table 21).

Table 21 Different forms of benign and malignant proliferation of tissue mast cells

Clinical picture

Clinical diagnosis

Evidence

In childhood, solitary or multiple skin nodules, some brownish

Localized mastocytosis

Histology

1 Sometimes transition

Diffuse brownish papules, with urticaria on irritation

Hyperpigmented spots, papules and/or dermo-graphism; histamine symptoms: flushing, headache, pruritus, abdominal spasms, shock

Malignant transformation, possibly with osteolysis, enlarged lymph nodes, splenomegaly, hepatomegaly

Migration of leukemic cells to peripheral blood

Urticaria pigmentosa

Typical clinical picture

Systemic mastocytosis

Histology

Malignant mastocyto-sis*

Histology

Acute mast cell leukemia

CBC (bone marrow)

* May occur de novo without preceding stages and without skin involvement.

* May occur de novo without preceding stages and without skin involvement.

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Responses

  • mimosa
    Is absolute basophilia seen in cml?
    6 years ago
  • Almaz Negassi
    Are eosinophils and basophils allergic response?
    6 years ago
  • faizan
    What disease can cause your eosinophil,basophil,and neutrophil counts are elevated?
    6 years ago
  • susanne
    What causes elevated monocytes and granulocytes?
    6 years ago
  • RODERIC
    What disease causes your eosinophil, basophil, and neutrophil count to be elevated?
    6 years ago
  • Santo Siciliano
    What happens when esoinophil, basophil and neutrophil counts are elevated?
    6 years ago
  • miranda
    Which is viral eosinophil or basophil?
    6 years ago
  • Coby
    What causes high basophil count?
    5 years ago
  • Fethawit Robel
    What causes elevated eosinophils and basophils?
    5 years ago
  • ted
    What causes Basophil blood cells to be elevated?
    5 years ago
  • karolin
    What causes basophil elevation?
    5 years ago
  • elga pisani
    What causes high basophils and eosinophils?
    5 years ago
  • jonas
    What is the main cause of high neutrophils eosinophils and basophils?
    5 years ago
  • ruaridh
    What is the effect if esnofil count is 6000?
    5 years ago
  • henna
    What causes high eosinpohil and basophil?
    4 years ago
  • rudolph
    What causes high basophil absolute?
    4 years ago
  • Kaarina
    What causes elevation of neutrophils and eosinophils?
    4 years ago
  • cora
    Can exercise cause basophil count to be high?
    4 years ago
  • Oran
    Are my elevated eosinophils caused by leukemia?
    4 years ago
  • nob
    What will be neutrophil, basophil, esonophil cells in malaria?
    4 years ago
  • gary ginn
    What happen if basophil and eosinophil will increase?
    4 years ago
  • Jarno
    What does increased eosinophils and basophils mean?
    4 years ago
  • Ellie-louise Mackenzie
    What causes high basophil and eosinaphil counts?
    4 years ago
  • beth reynolds
    What happen if basophil and eosinophil is high?
    4 years ago
  • patricia
    What causes an increase in basophils?
    4 years ago
  • Olga
    Do other kevels need to be elavated when ensinophils?
    4 years ago
  • Mathias
    What diseases causes high basophil count?
    4 years ago
  • lena
    What causes decrease in eosinophil %?
    3 years ago
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    What causes a basophil percentage increase?
    3 years ago
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    What infection causes fatigue and abnormal esonophils?
    3 years ago
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    Does henna increased eosinophil?
    3 years ago
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    Does basophils abs 0.13 mean mast leukemia?
    3 years ago
  • marcho
    What does basophilia and eosinophilia indicate?
    3 years ago
  • huriyyah
    What conditions can cause high eosinophils and basophils count in leukocytes?
    3 years ago
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    What are basophils and eusinophils?
    3 years ago
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    What diseases are linked to elevated basophils?
    3 years ago
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    What number of abs basoplil are seen in leukemia?
    3 years ago
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    What causes a rise in basophils?
    3 years ago
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    What leads to high basophils?
    3 years ago
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    When easoinphyl and basphyl count increases?
    3 years ago
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    Can mesh implants cause high basophils and lymphocytes?
    3 years ago
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    What might elevated esinophils basophils and neutrophils be?
    3 years ago
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    What is caused due to increase in meutrophils and eosinophils?
    3 years ago
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    What does raised eosinophils and basophils mean?
    3 years ago
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    What does it mean when your eosinophil, basophil, and neutrophil counts are elovated?
    3 years ago
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    Does a low eosphil mean any type of leukemia?
    3 years ago
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    What besophil 150 indicates?
    3 years ago
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    What happen when basophils and eosinophils percen?
    3 years ago
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    When neutrophil and eusinophil increase then what happen?
    3 years ago
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    Why would monocytes eosinophils and basophils be elevated?
    3 years ago
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    What counts as elevation of eosinophil count?
    3 years ago
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    WHAT DOES ELEVATED ESONOPHILS REPRESENT?
    3 years ago
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    What is a basophil count mine is 1% high?
    3 years ago
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    What is disease of high eosinophils and basophils?
    3 years ago
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    Can elevated basophils cause fever?
    3 years ago
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    3 years ago
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    Why are my monocytes and eosinophils high?
    3 years ago
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    3 years ago
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    3 years ago
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    3 years ago
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    3 years ago
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    How to increase monocytes and basophil count?
    3 years ago
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    3 years ago
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    3 years ago
  • Louise Walker
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    3 years ago
  • terry
    When eosinophils and basophils rise?
    3 years ago
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    3 years ago
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    3 years ago
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    3 years ago
  • mebrat brhane
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    3 years ago
  • luigia
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    3 years ago
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    3 years ago
  • Raymond
    What causes high eosinophil and basophil count?
    2 years ago
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    Can the increased percent of eosinophils n decreased percent of basophils leads to infection?
    2 years ago
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    WHEN MONOCYTES AND BASOPHILS ARE HIGH?
    2 years ago
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    2 years ago
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    2 years ago
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    Why does basophil are rarely seen?
    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    What could be the reason when basophil, esenophil are raised?
    2 years ago
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    2 years ago
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    2 years ago
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    Does basophin is increse in malaria?
    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    What causes slightly high basophil percent on blood work?
    2 years ago
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    What cause basophils counts in blood elevated?
    2 years ago
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    What indication does monocytes high,eosinophils high,basophil high and neutrophils low portray?
    2 years ago
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    Why woyld basophils and eosinophils elevate?
    2 years ago
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    How does malaria parasite affect monocyte, eosinophil and basophil?
    2 years ago
  • Lori
    What conditions may present due to high basophil?
    2 years ago
  • falco took-brandybuck
    What is absolute eosinophils?
    2 years ago
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    What is the absolute eosinophils and eosinphils?
    2 years ago
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    What does it mean if your basophilis count I'd high?
    2 years ago
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    Why are my dogs Monocytes, Eosinophils and Basophils high?
    2 years ago
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    What causesincreased basophil?
    2 years ago
  • frank
    What does the value of Basophil and Esnophil indicate?
    2 years ago
  • david
    What would make basephils decrease?
    2 years ago
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    What do elevated monocytes, esonophils and basophils indicate?
    2 years ago
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    What happen when basophils raise?
    2 years ago
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    What does a high baso mean in blood test?
    2 years ago
  • phyllis
    When eosophils/ basophils are high?
    2 years ago
  • Spencer Valdez
    When lymphocyte and basophil is increases?
    2 years ago
  • Aurora
    How to increase monocyte and basophil in blood?
    2 years ago
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    How to improve esnophills and basophills?
    2 years ago
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    What causes basophils to rise above the normal range in the children?
    2 years ago
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    What is basophill count in body?
    2 years ago
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    What does elevated basophils and neutrophils means?
    2 years ago
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    How to increase basophils and monocyte?
    2 years ago
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    2 years ago
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    Does lung disease cause basophilia?
    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    What infection does increased basophils depict?
    2 years ago
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    2 years ago
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    2 years ago
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    2 years ago
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    Why is basophilia ellevated?
    2 years ago
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    What happens when esinocount is more?
    2 years ago
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    2 years ago
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    2 years ago
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    Which is disease that cause basophelia?
    1 year ago
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    What is the reason of increase esinophils?
    1 year ago
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    What foods to eat to mature gr basophilia?
    1 year ago
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    What will happened if neutrofills esinophills increase?
    1 year ago
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    How to increase basophils count in blood?
    1 year ago
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    What is responsible for the increase of monocyste,basophils and esinophils?
    1 year ago
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    1 year ago
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    1 year ago
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    1 year ago
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    1 year ago
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    1 year ago
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    1 year ago
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    1 year ago
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    1 year ago
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    11 months ago
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    10 months ago
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