Bioinformatic Analyses

The nucleic acid sequences representing the clones in the subtracted library have been subjected to a series of bioinformatic analyses that are roughly divided into two parts. The first comprises automated searches of each clone to determine sequence homology to 1) known mouse proteins, 2) proteins from other species, and 3) expressed sequence tag (ESTs). In addition, a lack of homology to any publicly available sequence will also be revealed. The remaining analyses are undertaken by the individual annotating the clone and are explained subsequently. In short, the hand annotation provides a protein classification, putative function and, most importantly, a summary or notes with insights into the role of the gene product in the biological process. A summary schematic of the bioinformatic processing and hand annotation for each clone in StroCDB is presented (Fig. 2).

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