Transgenic Mouse

A transgenic mouse represents a gain of function mouse model and is usually designed to overexpress a gene of interest. By choosing an ubiquitous, tissue-specific or regulatable promoter, the expression of the transgene may be directed in space and time.

Several strategies may be chosen to express transgenes in an inducible fashion. These include the tet-on, tet-off, and ecdysone systems, in which the inducer and the responsive gene are introduced separately (16-20). An alternative approach is to use promoter elements that respond directly to an inducer, such as the interferon inducible Mx promoter (21) or fusion protein systems, in which the transgene is coupled with a modified ligand-binding domain of the estrogen or glucocorticoid receptors (22-25). These fusion proteins are inactive until the appropriate ligand is added.

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