Acute Marijuana Toxicity

Physiological effects: Dose-related tachycardia, blood pressure remains stable, increased appetite, dry (cotton) mouth, conjunctival injection, reduced intra-ocular pressure, bronchodilation, weakness, muscle tremors, urinary retention, low testosterone levelsimpotence. Psychological effects: Dose-related euphoria, relaxation, sensory alterations. Preexisting psychopathology may predispose to transient, acute psychotic reactions with paranoid delusions and hallucinations.

Management of Marijuana Intoxication

Motor vehicle and other transportation-related accidents: Marijuana is detected in 11-33% of cases (including mass transit and train accidents) and associated with a prolonged (>24 hours) loss of judgment and motor skills needed for safe vehicular operation. Acute psychotic reactions: Sedation with BZs. Pneumomediastinum: Rare and the result of deep inhalation with alveolar overdistension and rupture; supportive management with O2.

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