Chronic Marijuana Toxicity

Marijuana is an oily, dried fibrous material obtained from the Indian hemp plant, Cannabis sativa.

The most commonly used illegal substance in the United States.

The most commonly abused substance in the world after nicotine, alcohol, and caffeine. Considered a "gateway drug" by the DEA, NIDA, and the Substance Abuse and Mental Health Services Administration (SAMHSA).

Pharmacology

Tolerance and dependence: Resulting from repeated use.

Withdrawal syndrome: Irritability, restlessness, insomnia, and appetite loss.

COPD, oral and lung cancer:

Smoking-induced.

Congenital toxicity: Neonatal and early childhood neurobehavioral and developmental disturbances.

Male infertility: The result of combinations of low testosterone levels, low sperm counts, reduced sperm motility, and greater abnormal sperm morphology.

Delta-9-THC is the psychoactive component. Hashish (smoked in pipes) and hashish oil (mixed with tobacco and smoked): All are Cannabis derivatives that contain higher concentrations of THC.

THC is transported to the brain within 15 seconds of smoking to occupy specific cannabinoid receptors in the cerebral cortex.

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