Clinical Manifestations

Hyperthermia: Resulting from serotonin-induced high psychomotor hyperactivity and low heat dissipation from peripheral vasoconstriction.

CNS: Mydriasis, seizures, greater risk of cerebrovascular accidents (CVAs) = subarachnoid hemorrhage, intracranial hemorrhage, transient ischemic attacks.

Acute cardiovascular: Tachycardia, hypertension, tachyarrhythmias, myocardial infarction (MI), vascular endothelial damage and platelet aggregation and adhesion, subacute bacterial endocarditis (SBE) from septic emboli. Chronic cardiovascular: Coronary artery disease (CAD) and left ventricular hypertrophy

(LVH) = dilated cardiomyopathy, peripheral vascular disease, and acute aortic dissection. Pulmonary: Pneumomediastinum from deep inhalation with breath-holding, noncardiogenic pulmonary edema (NCPE) may result from adrenergic tone, pulmonary capillary leak, and pulmonary hypertension.

Skeletal muscle: Muscular hyperactivity and rigidity leading to muscle damage, high creatine phosphokinase (CPK) levels, rhabdomyolysis; myoglobinuria may lead to acute tubular necrosis (ATN) and acute renal failure (ARF). Gastrointestinal vasoconstriction: Gut ischemia and mesenteric thrombosis may lead to bowel necrosis with pneumatosis intestinalis. Uteroplacental and fetal: Spontaneous abortion, abruptio placenta, intrauterine growth retardation (IUGR), limb autoamputation, microcephaly, and low birth weight.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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