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Accidental insulin overdose: Most common cause of hypoglycemia due to combinations of insulin dose miscalculations, reduced caloric intake, increased exercise level or intercurrent infections or other illnesses. Long-acting (LA) sulfonylureas: Most common cause of non-insulin, drug-induced hypoglyce-mia, especially chlorpropamide LA and glybu-ride LA.

Market withdrawals: (1) The biguanide, phen-formin, was withdrawn in 1976, due to fatal lactic acidosis; (2) troglitazone (RezulinĀ®), a thiazolidinedione, was withdrawn in the 1990s, due to fatal hepatotoxicity.

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