Epidemiology

apap

APAP is contained in over 100 over-the counter (OTC) preparations, and fulminant liver failure from APAP overdose is the second most common cause of liver transplantation in the United States (No. 1 cause = hepatitis C). More than 100,000 analgesic overdoses per year, over 200 deaths, 46% due to APAP. APAP overdose hospitalizations are greater than all other overdose hospitalizations. APAP has replaced ASA as the analgesic-antipyretic of choice, especially for children secondary to safety profile, N-acetylcysteine (NAC) antidote, ASA toxicity, and Reye's Syndrome. APAP toxicity risk factors: low hepatic gluta-thione stores in alcoholics and malnourished; P450 enzyme induction from INH, rifampin, anticonvulsants, and chronic alcohol abuse.

Methyl salicylate (oil of wintergreen): 530 mg ASA/mL; 8 mL = 13,325 mg ASA tablets. As little as 4 mL of methyl salicylate can be lethal in children.

Alcohol No More

Alcohol No More

Do you love a drink from time to time? A lot of us do, often when socializing with acquaintances and loved ones. Drinking may be beneficial or harmful, depending upon your age and health status, and, naturally, how much you drink.

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