Pharmacokinetics and Uses

Pharmacokinetics: An antibacterial-antifungal halogenated hydrocarbon similar chemically to trichloroethanol, the active metabolite of chloral hydrate ("Mickey Finn"). Uses: Antimicrobial preservative in cosmetics and drugs, especially injectables, otic and ophthalmic topicals (contact lens cleansers).

CNS > cardiovascular > ocular:

CNS: Sedative-hypnotic, intoxicating effects, somnolence, then slurred speech, dysarthria, seizures.

Cardiovascular: Halogenated hydrocarbon that sensitizes the myocardium to catechol-amines with PVCs, serious tachyarrhyth-mias (Vtach, Vfib).

Ocular: Cytotoxic to corneal epithelium, but less damaging than benzalkonium chloride (BAC).

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