Vigabatrin

Acute toxicity: CNS > cardiovascular:

CNS: Ataxia, dysarthria, dystonia, clonus, choreoathetosis, seizures, stupor. Cardiovascular: Prolongs QT, widens QRS, torsades de pointes, VT. Chronic toxicity: Headache, diplopia, ataxia. Side effects: Aplastic anemia, Stevens-Johnson syndrome.

Treatment: AC, MDAC, abdominal x-ray for concretions, NaHCO3 for wide QRS, BZs for seizures, hemodialysis ineffective.

Phenytoin

Acute toxicity: CNS only, similar to gabapentin.

CNS: Acute psychosis. Chronic toxicity: Psychosis. Treatment: Supportive.

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