Contents

Part I

Development of the Immune System

Chapter 1

Development of the Rodent Immune System 3

Kenneth S. Landreth and Sarah V. M. Dodson

Chapter 2

Development of the Human Immune System 21

Ramona Leibnitz

Part II

Developmental Immunotoxicology: Models

Chapter 3

Risk Assessment Perspectives for Developmental Immunotoxicity 45

Carole A. Kimmel, Marquea D. King, and Susan L. Makris

Chapter 4

The Mouse as a Model for Developmental Immunotoxicology 65

M. Renee Prater, Benny L. Blaylock, and Steven D. Holladay

Chapter 5

The Rat as a Model for Developmental Immunotoxicology 77

Ralph J. Smialowicz

Chapter 6

The Pig as a Model for Developmental Immunotoxicology 103

Hermann J. Rothkotter, Eveline Sowa, and Reinhard Pabst

Chapter 7

The Nonhuman Primate as a Model of Developmental Immunotoxicity 117

Andrew G. Hendrickx, Pamela E. Peterson, and Norbert M. Makori

Part III

Developmental Immunotoxicant Exposure and Postnatal Immunosuppression

Chapter 8

Developmental Immunotoxicity of Halogenated Aromatic Hydrocarbons and Polycyclic Aromatic Hydrocarbons 139

Terry C. Hrubec, Benny L. Blaylock, and Steven D. Holladay

Chapter 9

Developmental Immunotoxicity of Chlordane 153

John B. Barnett, Laura F. Gibson, and Kenneth S. Landreth

Chapter 10

Toxicity of Lead to the Developing Immune System 169

Rodney R. Dietert and Ji-Eun Lee

Chapter 11

Developmental Immunotoxicity of Therapeutic Immunosuppressive Drugs 179

Robert M. Gogal, Jr. and Steven D. Holladay

Chapter 12

Mycotoxins and Other Miscellaneous Developmental Immunotoxicants 193

Terry C. Hrubec and Steven D. Holladay

Part IV

Developmental Immunotoxicant Exposure and Exacerbated Postnatal Immune Responses

Chapter 13

Perinatal Immunotoxicant Exposure and Autoimmune Disease 215

Benny L. Blaylock, S. Ansar Ahmed, and Steven D. Holladay

Chapter 14

Developmental Immunotoxicant Exposure and Exacerbated Postnatal

Immune Responses: Asthma 229

John M. Armstrong, Deborah Loer-Martin, and Ramona Leibnitz

Part V

Neuroimmune Interactions

Chapter 15

Developmental Neurotoxicity and Postnatal Immune Deficits Patricia V. Basta

Chapter 16

Neuroendocrine-Immune Interactions: Impact of Gender, Negative Energetic Balance Condition, and Developmental Stage on the Mechanisms of the Acute Phase Response of the Inflammatory Process in Mammals 303

Eduardo Spinedi, Néstor B. Pérez, and Rolf C. Gaillard

Index

Part I

Development of the Immune System

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