Michael D West Introduction to Aging

In the course of human development, one observes a progressive increase in body size and maturation until sexual maturity is attained. Having reached this summit, the body then shows a progressive degeneration with the passage of time, a phenomenon frequently referred to as aging. The reason for the maturation phase may seem obvious, but why we age has remained a conundrum. As G.C. Williams once observed, It is indeed remarkable that after a seemingly miraculous feat of morphogenesis a complex...

Metalloproteinases in Chronic Lung Injury

Lung emphysema is a major pathological condition usually associated with cigarette smoking. The disease is characterized by abnormal and permanent enlargement of respiratory regions of the lung distal to the terminal bronchioles, accompanied by the destruction of the alveolar septa.37 The disease provokes the disappearance or severe disturbance of the orderly structure of the pulmonary acinus where gas exchange occurs, leading to progressive and irreversible respiratory insufficiency....