Magnetic Dumbbells

Magnetic particles greatly facilitate the manipulation of dumbbells by the opportunity they offer to separate them from the excess reagents and to drive them at a desired location. In the Laser Magnetic Immunoassay of Mizutani 48 , viruses captured on microbeads are let to react with antibodies labelled with magnetic particles. Magnetically labelled antigens are attracted and concentrated at one point of the surface, onto which is focused a laser beam, making an interference fringe whose...

Antigen Detection

Among numerous antigens whose presence and concentration are often assayed by biological sampling, a physiological parameter is chosen as a model illustrating the immunological detection of proteins by LATMAG Fig. 8 . Thyroid-stimulating hormon TSH is a major regulating factor of hormone synthesis and secretion, and sensitivity to that parameter is needed for the diagnosis of hyperthyroidism 58 . To demonstrate that several detection methods are compatible with LATMAG, dumbbell suspensions are...

Indirect Agglutination Test

Indirect Agglutination Test

Recent years have heralded an increase in the use of clinical diagnostic methods involving immunological procedures because they are specific and have high sensitivity. Of the many heterogeneous and homogeneous immunological assay methods available, those based on the agglutination of latex particles continue to be widely used in biology and medicine for the detection of small quantities of an antibody or antigen in a fluid test sample. Some advantages of these assays are that the procedures...