Additional Effects

Antimalarials lowered the total cholesterol, low-density lipoprotein cholesterol, and triglyceride concentrations in patients with SLE, especially those who were concomi-tantly treated with corticosteroids (Borba and Bonfa 2001, Tam et al. 2000). Chloroquine lowered the blood glucose concentrations. These effects - reduction of the con-

centrations of lipids and blood sugar and the inhibition of platelet aggregation -could lower the risk of atherosclerosis (Barthel et al. 1996, Petri 1996, Rahmann et al. 1999, Wallace et al. 1993). Because SLE may be an additional risk factor for atherosclerosis, early therapy is discussed (Urowitz et al. 2000).

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