Adhesion Molecules

A necessary step for lymphocytes to leave the blood vessel and migrate to the target organ, in this case the skin, is the expression of CAMs. CAMs are necessary for cell-cell and cell-matrix contact in inflammatory reactions (Chapman and Haskard 1995, McMurray 1996, Shiohara et al. 1992, Springer 1990).

ICAM-1 and vascular adhesion molecule-1 (VCAM-1) are members of the immunoglobulin gene superfamily and are induced or up-regulated on several cell types in the skin during inflammation. E-selectin is exclusively expressed by activated endothelial cells (Frenette and Wagner 1996). Soluble forms of these CAMs have been reported and are possibly related to disease activity in LE as well as many other neo-plastic and inflammatory conditions (Gearing and Newman 1993).

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