Adverse Effects Hemolysis

Hemolysis with Heinz-body formation is the second most important hematologic side effect of dapsone. Patients treated with 150 mg/day of dapsone will have a significant decrease in the hemoglobin level of almost 2 g/dl. Individuals with glucose-6-dehydrogenase deficiency have an even greater decrease in the hemoglobin level. In vivo and in vitro studies have demonstrated a direct involvement of hydroxylamines in hemolysis. Also, the presence of oxygen-free radicals seems to play a certain role. However, hemolysis does not correlate with the acetylator status of the patient.

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