Animal Models

It is interesting to note that although there are very few animal models of drug-induced idiosyncratic drug reactions, there seem to be more animal models of drug-induced lupus than other types of idiosyncratic drug reactions. As mentioned previously, these models include penicillamine- and mercury-induced autoimmunity in Brown Norway rats (Donker et al. 1984, Tournade et al. 1990), propylthiouracil-

induced lupus in cats (Aucoin et al. 1985), and trichloroethylene-induced autoimmunity in MRL+/+ mice (Kilburn and Warshaw 1992).

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