Anticardiolipin Antibodies

The anticardiolipin antibody is one of the serologic markers used to diagnose the antiphospholipid syndrome. The anticardiolipin antibody was positive in 31% of patients with CLE, whereas in patients with SLE its prevalence is slightly higher. Although anticardiolipin antibody is seen in 30%-40% of patients with SLE and CLE, it has not been associated with any complications (e. g., spontaneous abortions or arterial and/or venous occlusive disease) in CLE (Mayou et al. 1988).

Table 23.3. Laboratory data comparing cutaneous lupus erythematosus (CLE) and systemic LE (SLE)

Parameter

Prystowski

O'Loughlin

Millard and

Callen

Wallace et al.

Pistiner et al.

CLE vs SLE

Tebbe et al.

et al. 1975

et al. 1978

Rowell 1979

1982

1992

1991

P Value, Wallace et al. 1992

1997

Cases (n)

80 CLE

69 CLE

92 CLE

56 CLE

67 CLE

464 SLE

245 CLE

Year

1975

1978

1979

1982

1990

1991

1991

1997

Anemia (%)

2

10

27

0

7

30

0.0001

-

Hemolytic anemia (%)

-

-

-

0

0

8

0.009

-

Leukopenia (%)

0

14

12

10

30

51

0.002

-

Thrombocytopenia (%)

-

-

4

-

2

16

0.0001

-

Positive ANAs (%)

4

49

25

22

63

96

0.0001

29

Low C3 (%)

8

-

-

0

10

39

0.0001

-

High anti-ds-DNA (%)

0

0

-

4

8

40

0.0001

35

Positive anti-RNP (%)

-

-

-

5

2

14

0.081

-

Positive RF

(latex fixation) (%)

1

6

13

21

9

23

0.02

-

Positve anti-RoSSA (%)

-

-

-

-

4

18

0.003

-

Positive anticardiolipin

antibody (%)

-

-

-

-

31

38

0.53

-

High sedimentation

rate (%)

56

45

20

43

31

54

0.001

56

ANAs, antinuclear antibodies; ds, double-stranded; RF, rheumatoid factor.

ANAs, antinuclear antibodies; ds, double-stranded; RF, rheumatoid factor.

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