Anticonvulsants

Several anticonvulsants, such as carbamazepine, phenytoin, and ethosuximide, are associated with a low but significant incidence of drug-induced lupus (Beernink and Miller 1973, Jain 1991). The incidence of circulating ANAs in patients treated with carbamazepine is reported to be 78% (Alarcon-Segovia et al. 1972). Patients are often taking more than one anticonvulsant, so it is often difficult to be certain what drug is responsible. The aromatic anticonvulsants are also associated with a hypersensitivity syndrome in which there is some overlap with the lupus-like syndrome, but it is more acute in onset (Shear and Spielberg 1988).

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