According to several reports IL-10 seems to play a pivotal role in the pathogenesis of SLE, although its exact function in vivo is not fully understood (Llorente et al. 2000). Among many immunomodulating activities, IL-10 is known to inhibit the production of several proinflammatory cytokines and to promote a Th2 immune response. Accordingly, IL-10 promotes B-cell differentiation and hyperactivity, but at high doses also seems to have an inhibitory effect on B-cell functions. Moreover, IL-10 upregulates Fas ligand-expression in vitro which may result in augmented T-cell death in vivo (Solsky and Wallace 2002). In mice IL-10 inhibits antigen presentation and Th1-lymphocyte activation (Yin et al. 2000). In patients with SLE an increased production of IL-10 by peripheral blood mononuclear cells was found to be associated with overproduction of pathogenic auto-antibodies. Therefore, it seemed reasonable to investigate whether blocking IL-10 may provide an useful approach to treat autoimmune diseases such as LE. Accordingly, six steroid-dependent patients with SLE were treated for 21 consecutive days with intravenous infusion of anti-IL-10 (20mg/d). Patients experienced a significant decrease in disease activity and were able to reduce concomitant steroid medication. In addition, a significant improvement of vasculitis and skin lesions was observed. Clinical scores remained stable through a follow-up of 6 months and no significant adverse events have been reported (Llorente et al. 2000).

Hair Loss Prevention

Hair Loss Prevention

The best start to preventing hair loss is understanding the basics of hair what it is, how it grows, what system malfunctions can cause it to stop growing. And this ebook will cover the bases for you. Note that the contents here are not presented from a medical practitioner, and that any and all dietary and medical planning should be made under the guidance of your own medical and health practitioners. This content only presents overviews of hair loss prevention research for educational purposes and does not replace medical advice from a professional physician.

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