Association with Tumors

In rare cases of DLE, the development of skin tumors is reported. Basal cell carcinoma, keratoacanthoma, and squamous cell carcinoma may develop on atrophic scars as a long-term complication of DLE lesions (Dabski et al. 1986, Fanti et al. 1989, Halder and Bridgeman-Shah 1995, Stavropoulo et al. 1996). Cutaneous squamous cell carcinoma rarely shows distant metastasis, however, the tendency for LE-associated carcinoma to metastasize has been observed more frequently, with the rates varying from 0.5% to 2% (Millard and Barker 1978).

SCLE is regarded as a facultative paraneoplastic syndrome by some authors, and cases have been described in association with various malignant tumors. In nearly 20 patients described, lung cancer and breast cancer were most frequently found. However, malignant tumors in other organ systems (stomach, liver, uterus, and brain) have been also reported. The patients described did not differ in clinical presentation, histopathologic findings, and serologic profile from other patients with SCLE except for a higher age at onset (Castanet et al. 1995, Ho et al. 2001, Kuhn and Kaufmann 1986, Richardson and Cohen 2000,Trueb andTrueb 1999). First disease manifestation of SCLE in older patients (>50 years) may possibly indicate the occurrence of the disease as a paraneoplastic syndrome.

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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