This antimetabolite of the purine synthesis represents the classic drug in autoimmune and rheumatologic disorders to be combined with glucocorticosteroids. Monotherapy may take 2-8 weeks to show clinical response (Abu-Shakra et al. 2001, Ashinoff et al. 1988, Callen et al. 1991, Tan et al. 1997, Tsokos et al. 1985). Before initiation of the therapy, activity of the metabolizing enzyme thiomethyltransferase should be evaluated to individually adapt the dosage of azathioprine and lower the incidence of side effects. With normal enzyme levels, doses of 2 mg/kg body weight and greater are recommended. Side effects include disturbances in blood cell counts and liver enzyme levels. Initially, these laboratory parameters should be checked at weeks 2, 4, and 8, and thereafter every 3 months. The incidence of infections seems to be only slightly increased in contrast to a distinct increase of tumors on long-term treatment. This, however, seems to apply to almost any immunosuppressive and most immunomodulatory drugs.

Hair Loss Prevention

Hair Loss Prevention

The best start to preventing hair loss is understanding the basics of hair what it is, how it grows, what system malfunctions can cause it to stop growing. And this ebook will cover the bases for you. Note that the contents here are not presented from a medical practitioner, and that any and all dietary and medical planning should be made under the guidance of your own medical and health practitioners. This content only presents overviews of hair loss prevention research for educational purposes and does not replace medical advice from a professional physician.

Get My Free Ebook

Post a comment