Cefuroxime axetil is a p-lactamase-stable, second-generation, oral cephalosporine, which in vivo is rapidly hydrolysed to the active compound cefuroxime. It has a broad spectrum of antibacterial activities that encompasses methicillin-sensitive staphylococci, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, group A p-hemolytic streptococci, and several other bacteria. Major indications for cefuroxime are lower and upper respiratory tract infections and bacterial skin diseases. Moreover, this drug also seems to exert some immunomodulating activities. In one study, cefuroxime axetil was used to treat three patients with SCLE (Rud-nicka et al. 2000). With a dose of 500 mg daily, skin lesions cleared almost completely within 30-40 days. Moreover, in one patient, leukopenia, the erythrocyte sedimentation rate, and arthralgia improved. None of the patients experienced severe side effects. A not yet fully understood immunomodulating mechanism seems to be responsible for the improvement in SCLE. This activity seems to be specific for cefuroxime axetil, since other related antibiotics were not effective (Rudnicka et al. 2000).
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