Chemistry

Retinoids are naturally occurring compounds and synthetic derivatives of retinol (vitamin-A alcohol) that show vitamin A activity. There are three generations of synthetic retinoids today. Manipulation of the polar group and the polyene side chain of vitamin A forms the first generation of retinoids, which includes tretinoin (all-trans-retinoic acid), isotretinoin (13-cis-retinoic acid), and alitretinoin (9-cis-retinoic acid). The aromatic retinoids, etretinate and acitretin, are produced by replacing the cyclic end group of vitamin A with different substituted and nonsubstituted ring systems and are synthetic retinoids of the second generation. The third-generation retinoids, tazarotene and adapalene, known as polyaromatic compounds, are topical agents for the treatment of psoriasis and acne (Fig. 27.3). Bexarotene is also a third-generation retinoid and is approved for the systemic treatment of cutaneous T-cell lymphoma (Brecher and Orlow 2003, Orfanos et al. 1987).

Fight Acne

Fight Acne

I am sure that every one of you is familiar with acne. Almost all of us got this skin disorder, right? Well, technically known as acne vulgaris, this skin disorder affects millions of people from different walks of life, annually.

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