Contents

Part I

Introduction

1 What is Autoimmunity: Basic Mechanisms and Concepts 3

Thomas M. Herndon, George C. Tsokos

2 Photoimmunology 19

Stefan Beissert, Annette Mehling, Thomas Schwarz

3 The Epidemiology of Lupus Erythematosus 33

Sonia Jimenez, Ricard Cervera, Miguel Ingelmo, Josep Font

4 Historical Background of Cutaneous Lupus Erythematosus 45

Percy Lehmann

Part II

Classification and Clincial Aspects of Cutaneous Lupus Erythematosus

5 Classification of Cutaneous Lupus Erythematosus 53

Annegret Kuhn, Thomas Ruzicka

6 Clinical Manifestations of Cutaneous Lupus Erythematosus 59

Annegret Kuhn, Richard D. Sontheimer, Thomas Ruzicka

7 Nonspecific Cutaneous Manifestations of Systemic Lupus

Erythematosus 93

Thomas T. Provost

8 Cutaneous Lupus Erythematosus During the Neonatal and Childhood Periods 107

Lela A. Lee

9 Drug-Induced Lupus Erythematosus 117

Jack Uetrecht

10 Association of Cutaneous Lupus Erythematosus with Other Dermatological Diseases 133

Kyrill Pramatarov, Nikolai Tsankov

11 Clinical Differential Diagnosis of Cutaneous Lupus Erythematosus 147

Florian Weber, Peter Fritsch

12 Photosensitivity in Lupus Erythematosus 161

Percy Lehmann, Annegret Kuhn

13 Relationship Between Cutaneous and Systemic Lupus Erythematosus ... 177 Christof Specker, Matthias Schneider

14 Prognosis of Cutaneous Lupus Erythematosus 187

Beate Tebbe, Constantin E. Orfanos

Part III

Pathogenesis and Pathologic Features of Cutaneous Lupus Erythematosus

15 Molecular Genetics of Cutaneous Lupus Erythematosus 205

Thomas P. Millard

16 Experimental Models of Lupus Erythematosus 221

Fukumi Furukawa

17 Apoptosis in Lupus Erythematosus 239

Felipe Andrade, Antony Rosen, Livia A. Casciola-Rosen

18 Pathogenesis of Cutaneous Lupus Erythematosus:

The Role of Ultraviolet Light 251

Michele L. RosENbAUM, Victoria P.Werth

19 The Role of T Cells and Adhesion Molecules in Cutaneous Lupus

Erythematosus 267

Filippa NYbERg, EijA Stephansson

20 The Role of Dendritic Cells in Cutaneous Lupus Erythematosus 283

Andreas WoLLENbERG, STEfANiE Wetzel

21 Histologic Findings in Cutaneous Lupus Erythematosus 297

Christian A. Sander, Amir S. Yazdi, Michael J. Flaig, Peter Kind

22 Immunopathology of Cutaneous Lupus Erythematosus 305

Michael Meurer

23 Laboratory Features of Cutaneous Lupus Erythematosus 311

Shuntaro Shinada, Daniel J. Wallace

24 Antinuclear Autoantibodies in Cutaneous Lupus Erythematosus:

Biochemical and Cell Biological Characterization of Ro/SSA 323

Anna von Mikecz

Part IV

Treatment and Management of Cutaneous Lupus Erythematosus

25 Topical Treatment of Cutaneous Lupus Erythematosus 337

Percy Lehmann

26 Antimalarials 347

Falk R. Ochsendorf

27 Dapsone and Retinoids 373

David Bacman, Annegret Kuhn, Thomas Ruzicka

28 Thalidomide in Cutaneous Lupus Erythematosus 391

Yousuf Karim, Maria J. Cuadrado

29 Immunosuppressive Drugs in Cutaneous Lupus Erythematosus 403

Michael Sticherling

30 Experimental Therapies in Cutaneous Lupus Erythematosus 419

Stefan W. Schneider, Thomas A. Luger

31 Management of Cutaneous Lupus Erythematosus 437

Jeffrey P. Callen

Acknowledgements 445

Subject Index 447

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