Dapsone (4,4'-diaminodiphenylsulphone) has been in clinical use for more than 60 years. It is widely used in the treatment of a variety of infectious diseases, including leprosy and malaria, and it has some action against other parasites. In addition, it has been effective in the treatment of a diversity of cutaneous disorders, particularly those characterized by a neutrophilic infiltrate but also cutaneous manifestations of lupus erythematosus (LE), erythema nodosum, cutaneous vasculitides, pyoderma gangrenosum, bullous dermatoses, and dermatitis herpetiformis (Lang 1979, Mok et al. 1998).

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