Dapsone

Dapsone's use is limited by its toxic effects, which include sulfhemoglobinemia and methemoglobinemia, a dose-related hemolytic anemia, a "dapsone hypersensitivity syndrome," and aplastic anemia (Meyerson and Cohen 1994, Mok et al. 1998). All patients treated with dapsone should have their baseline G-6-PD level checked. The drug should not be given to patients with low levels. Complete blood cell counts should be checked every 2 weeks for the first 3 months, then every 2 months thereafter. Toxic hepatitis and cholestatic jaundice have been reported early in therapy. Hyperbilirubinemia may occur more often in G-6-PD-deficient patients. Baseline and subsequent monitoring of liver function is recommended.

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