Dermal DCs Definition

In 1986, Headington (Headington 1986) described the dermal dendrocyte as DCs of the human dermis. These DDCs appear nowadays as an ill-defined, probably hetero-genous, dendritically shaped cell type within the dermal compartment exhibiting a considerable degree of immunophenotypic and functional heterogeneity. Some aspects of DDCs have been studied, for example, in psoriasis (Nestle et al. 1994), but no general or unifying concept of DDC biology has been established. The role of DDCs in the pathogenesis of inflammatory skin diseases is currently unclear.

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