Dermal Mucinosis

Histologic demonstration of dermal mucin deposition is commonly detected in biopsy specimens of LE lesions. Sometimes, flesh-colored papulonodular cutaneous mucin deposition occurs. Rarely, massive mucin deposition has been reported in Japanese patients with SLE (Maruyama et al. 1997).

The author and other investigators have seen a group of Japanese patients possessing anti-Ro/SSA antibodies who have demonstrated a very peculiar "donut-like" erythematous plaque-like lesion (Nishikawa and Provost 1991, Teramato et al. 1989). They have been generally described under the rubric of Sjogren's syndrome, although some investigators have proposed that these lesions are similar to SCLE (Ruzicka et al. 1991, Watanabe et al. 1997). This author, based on his experience, believes that this is a very distinctive lesion. Histologically, mucin deposition is prominent, and this author believes that the mucin deposition, which is hydroscopic, is responsible for the prominent edematous features of the lesions.

In general, the papulonodular cutaneous mucin deposition detected in patients with SLE responds to prednisone or antimalarial drug therapy.

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