Distribution

Dapsone is ca. 70%-90% bound to plasma protein, and its monoacetylated metabolite (monoacetyldapsone [MADDS]) is almost entirely (99%) protein bound. Dap-sone seems to be distributed throughout the body, including the skin, liver, kidneys, and erythrocytes. Dapsone crosses the blood-brain barrier and the placenta and is excreted in breast milk. Nevertheless, there are no reports of harmful effects on the fetus in utero, and only a few cases of neonatal hemolysis have been described (Zhu and Stiller 2001, Zuidema et al. 1986).

Fig. 27.1. Chemical structure of dapsone and its major metabolite

Dapsone

Dapsone

H,N NHCOCH3

Monoacetyldapsone

Monoacetyldapsone

Hair Loss Prevention

Hair Loss Prevention

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