Distribution

Isotretinoin is highly lipophilic and is therefore extensively (>99%) bound to plasma proteins, mainly albumin. It has been shown that isotretinoin is not stored in adipose tissue, and there is not specific retention in any organ.

As with isotretinoin, acitretin is to a great extent (98%) bound to plasma proteins, mostly to albumin, caused by its high lipophilicity. Acitretin is not stored in adipose tissue. Isotretinoin and acitretin seem to cross the placenta and to be excreted in breast milk (Orfanos et al. 1987, Wiegand and Chou 1998a).

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