Distribution

Isotretinoin is highly lipophilic and is therefore extensively (>99%) bound to plasma proteins, mainly albumin. It has been shown that isotretinoin is not stored in adipose tissue, and there is not specific retention in any organ.

As with isotretinoin, acitretin is to a great extent (98%) bound to plasma proteins, mostly to albumin, caused by its high lipophilicity. Acitretin is not stored in adipose tissue. Isotretinoin and acitretin seem to cross the placenta and to be excreted in breast milk (Orfanos et al. 1987, Wiegand and Chou 1998a).

Hair Loss Prevention

Hair Loss Prevention

The best start to preventing hair loss is understanding the basics of hair what it is, how it grows, what system malfunctions can cause it to stop growing. And this ebook will cover the bases for you. Note that the contents here are not presented from a medical practitioner, and that any and all dietary and medical planning should be made under the guidance of your own medical and health practitioners. This content only presents overviews of hair loss prevention research for educational purposes and does not replace medical advice from a professional physician.

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