Function

A major function of DDCs is their capacity to phagocytose large antigen-antibody complexes. This extensive phagocytic function is also demonstrated by their capacity to take up carbon particles, hemosiderin, or melanin and distinguishes them from LCs (Headington 1986).

The function of DDCs in the pathogenesis of LE is unclear. In psoriasis plaques, many DDCs have been identified that were able to induce T helper (Th) 1-type cyto-kines on phytohemagglutinin (PHA) addition, suggesting an important autostimula-tory capacity (Nestle et al. 1994).

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