Gastrointestinal Involvement

Retinoids may alter liver function tests, most commonly the transaminases but also other tests (alkaline phosphatase, lactic dehydrogenase, and bilirubin). Elevations of transaminase levels occur in approximately 15% of patients, but they generally return to normal within 2-4 weeks, even when therapy is continued. Severe hepatotoxic reactions resulting from retinoid use are rare and idiosyncratic. However, a correlation between long-term retinoid therapy and chronic liver toxicity has not been demonstrated. Nonspecific gastrointestinal side effects, such as nausea, diarrhea, and abdominal pain, have been reported with isotretinoin therapy but are infrequent. Although the oral administration of isotretinoin has been linked with inflammatory bowel disease flare-up, a causal relationship has not been established. In fact, isotretinoin has been given to patients with known Crohn's disease and ulcerative colitis without complications (Brecher and Orlow 2003, Ellis and Krach 2001, Katz et al. 1999, Peck and DiGiovanna 1999).

How To Win Your War Against Irritable Bowel Syndrome

How To Win Your War Against Irritable Bowel Syndrome

Is Irritable Bowel Syndrome Ruining Your Life? Have You Stopped Living The Way You Used To? Do You Feel Life Has Turned It's Back On You? Yes, It's True IBS Can Be A Grueling, Debilitating, Experience That Makes Living Truly A Nightmare Finally Learn Some Little-Known, But Highly Effective Ways To Relieve Irritable Bowel Syndrome Put An End To This Unbearable Pain, And Get Back To Enjoying The Beauty Of Life Once Again You Deserve It

Get My Free Ebook


Post a comment