Gold

Both parenteral (aurothioglucose) and oral gold (auranofin) have been successfully used for DLE, the latter at initial doses of 3mg/day (Dalziel et al. 1986, Duna 1995, Steinkjer 1995, Werth 2001). An open trial showed improvement or complete remission in 19 of 23 patients (Steinkjer 1995). Infiltrated, but not hyperkeratotic, plaques were responsive. Diarrhea, nausea, and headache as well as renal and hematologic disturbances represent limiting side effects. Nonscarring forms of CLE seem to respond best. Possible lichenoid drug exanthema during the course of gold treatment should be dissected from LE-associated rash.

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