A white discoloration is almost exclusively found in blond, ginger, or light-brown hair (about 60 case reports; see Ochsendorf and Runne 1991).These hair colors mainly are caused by pheomelanin, the syntheses of which is impaired by chloroquine. A toxic effect of chloroquine to the melanocyte was also reported (Ash et al. 1997). Daily dose seems to be the most relevant factor (mostly >400 mg/day), as a reduction in the daily dose to 250 mg/day was followed by recovery of the hair color despite continuation of therapy.

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