In Cutaneous Lupus Erythematosus

Andreas Wollenberg, Stefanie Wetzel

Lupus erythematosus (LE) is an autoimmune disorder associated with specific and nonspecific skin lesions, UV sensitivity, anti-DNA antibodies, and increased interferon (IFN)-a/p production. Although the histopathology of LE is well defined, the pathogenesis of skin lesions in LE is still insufficiently understood and does not explain all the clinical aspects of LE. Approximately 55% of patients with systemic LE (SLE) develop clinically distinctive skin lesions, whereas patients with specific LE skin disease, such as subacute cutaneous LE (SCLE) or chronic discoid LE, may never develop systemic manifestations (Dubois and Tuffanelli 1964).LE is considered an autoimmune disease. Because several autoimmune processes have been described in LE, it also has been assumed that the cutaneous lesions are based on an autoimmune etiology.

Dendritic cells (DCs) of the skin are believed to present relevant autoantigens to T cells, thus starting the unwanted immune responses of CLE. Several studies have investigated and found alterations in DCs in the skin lesions of LE. This chapter covers our current knowledge of the different types of DCs in the pathogenesis of CLE.

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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