Inhibition of Apoptosis

The first pathogenic mechanism of lupus that was discovered in an animal model was a defect in apoptosis that prevented the deletion of autoreactive T cells (Watanabe-Fukunaga et al. 1992). One article reported that chlorpromazine increased apoptosis in lymphoblasts (Hieronymus et al. 2000); however, the effects were studied in vitro, and it is unclear whether the effects seen in this system are representative of the effects that occur in vivo. Procainamide and hydralazine had no effect on apoptosis, but it is unlikely that significant amounts of reactive metabolite would be produced in this system. To my knowledge, no work has been done in vivo to determine the effects on apoptosis of drugs associated with the induction of lupus.

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