One of the few other drugs that contain a hydrazine group is isoniazid. The incidence of circulating ANAs in patients treated with isoniazid is approximately 20% (Roth-field et al. 1978). There are several reports of isoniazid-induced lupus; however, the incidence is significantly lower than that associated with hydralazine therapy, and it is difficult to estimate. Isoniazid therapy is also associated with a relatively high incidence of idiosyncratic liver toxicity (Maddrey and Boitnott 1973).
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