Langerhans Cells

LCs were discovered by Paul Langerhans in 1868 when he applied a gold chloride stain to cutaneous tissue. Based on the available knowledge, he considered them to be of neural origin because of their dendritic shape (Langerhans 1868). Later, LCs were recognized as professional APCs capable of initiating primary and secondary responses in the skin immune system (Silberberg-Sinakin et al. 1976). Today, LCs are considered the prototype of immature DCs and represent the only major DC type in the normal human epidermis (Wollenberg and Bieber 2002).

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