Reversible hepatitis was reported in single cases. Blood

The most serious adverse reaction of quinacrine is aplastic anemia. The incidence increases with drug dose and duration of therapy. Only one case was reported with a daily dose of 100 mg (Wallace 1989). In every second patient, a premorbid lichen planus rash preceded the aplastic anemia. So, therapy has to be discontinued if a lichen planus rash occurs. The incidence of this aplasia with regular control of blood cell counts is estimated to be 1:500,000 (Wallace 1989).

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