Ljp394

LJP-394 (abetimus) is an anti-anti-ds-DNA B-cell toleragen consisting of four synthetic double-stranded oligodeoxyribonucleotides. Toleragens have been shown to suppress antibody synthesis by targeted B cells. They cross-link B-cell surface antibodies without providing the second T-cell activating signal, thereby making the B cells unresponsive. The consequence is a down-regulation of anti-ds-DNA antibody, an autoantibody presumed to be a causative factor in lupus nephritis. Therefore, a double-blind placebo-controlled study including 230 SLE patients with a history of renal disease has been performed (Alacron-Segovia et al. 2000, Furie et al. 2001, McNeely et al. 2001). Although the initial evaluation of the results indicated no efficacy in the improvement of renal disease, upon a second analysis it appeared that LJP-394 provided clinical benefit only in those patients with high levels of anti-ds-DNA antibodies. Moreover, the compound was well tolerated with a low risk for serious side effects (Wallace 2001b).

Hair Loss Prevention

Hair Loss Prevention

The best start to preventing hair loss is understanding the basics of hair what it is, how it grows, what system malfunctions can cause it to stop growing. And this ebook will cover the bases for you. Note that the contents here are not presented from a medical practitioner, and that any and all dietary and medical planning should be made under the guidance of your own medical and health practitioners. This content only presents overviews of hair loss prevention research for educational purposes and does not replace medical advice from a professional physician.

Get My Free Ebook


Post a comment