Lupus Erythematosus and Alopecia Areata

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Diffuse alopecia and especially frontal alopecia due to increased hair fragility is more typical for SLE. Scarring alopecia is a frequent clinical feature of DLE and SLE. Alopecia areata is rarely associated with LE. In a large study of 736 patients with alopecia areata, only 2 had DLE and 2 had SLE (Muller and Winkelmann 1963). In 1975, Lerchin et al. (Lerchin et al. 1975) reported a single case of DLE associated with alopecia areata. Werth et al. (Werth et al. 1992) found 4 patients with alopecia areata in a group of 39 patients with LE. Two of the patients had DLE and two had SLE. The first of the reported patients had scarring alopecia as well. In each patient, continuous granular deposits of IgG at the dermoepidermal junction were detected. The authors believed that the incidence of alopecia areata in patients with LE is increased because of the common lines of evidence of both diseases.

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