Pyoderma gangrenosum is associated with many systemic diseases, including SLE. The first reported case with coexisted pyoderma gangrenosum is the patient described by Olson in 1979. This association has been rarely reported, and all of the cases are not precise toward the condition of pyoderma gangrenosum (see Pinto et al.

1991). Among the several cases reported is one with hydralazine-induced SLE presenting as pyoderma gangrenosum-like ulcers (Peterson 1984). There are occasional studies about the association of LE with hereditary angioedema. All subtypes of LE have been reported to be coexistent with hereditary angioedema (see Gudat and Bork 1999). Duhra et al. (Duhra et al. 1990) reported in 1990 a female patient who developed DLE 6 years after the onset of hereditary angioedema. They tried to explain the coexistence of both diseases by C1 inhibitor deficiency, which can induce DLE. Duhra et al. believed that this association is rare, but its recognition is important because both diseases respond to danazol therapy. A single case showing an association between DLE and pseudoainhum has been reported (Sharma et al. 1998). Pseudoain-hum is a rare dermatologic complication presenting as a constricting band around the digits. The reported patient was a 32-year-old male with 10 years duration of DLE. Pseudo-ainhum affected several digits of both hands. Vitiligo also has been reported predominantly in association with DLE. In most cases, vitiligo appeared first and DLE secondary into the lesions of vitiligo. DLE appeared in the vitiligo lesions usually (see Forestier et al. 1981). In some cases, vitiligo lesions appeared simultaneously with DLE (Wlotzke 1996). Calcinosis cutis appears in cutaneous LE rarely. Rothe et al. (Rothe et al. 1990), in 1990, described three patients with SLE and extensive calcinosis cutis. One patient had discoid lesions that ulcerated subsequently, but calcinosis was not apparent. LE and DLE is recognized as a facultative precancerosis. LE-associated skin cancers are observed usually on the face and scalp. The skin cancers observed most often are squamous cell carcinoma and keratoacanthomas, but basal cell carcinoma also has been reported (Stavropoulos et al. 1996)

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