Outlook on Lupus Erythematosus and DCs

Studies have confirmed the presence of large numbers of T lymphocytes in the dermis of LE (Synkowski et al. 1983). LCs are diminished and IDECs are almost absent in the epidermis of LE lesions. Instead, PDCs seem to accumulate in lesional epidermis and dermis (Farkas et al. 2001, Wollenberg et al. 2002). In the dermal compartment, DDC numbers are increased (Mori et al. 1994).

In terms of LE pathophysiology, PDCs may be regarded as the most interesting DC type because of their accumulation in the skin lesions of LE as well as their capability to produce type 1 IFN. It is unclear whether the decreased number of LCs and IDECs in the inflamed epidermis is causally linked with the epidermal accumulation of PDCs. Further investigations are warranted to clarify the complex and difficult interplay of several immunologic factors and cells in the pathogenesis of LE.

Hair Loss Prevention

Hair Loss Prevention

The best start to preventing hair loss is understanding the basics of hair what it is, how it grows, what system malfunctions can cause it to stop growing. And this ebook will cover the bases for you. Note that the contents here are not presented from a medical practitioner, and that any and all dietary and medical planning should be made under the guidance of your own medical and health practitioners. This content only presents overviews of hair loss prevention research for educational purposes and does not replace medical advice from a professional physician.

Get My Free Ebook

Post a comment