Pharmacokinetics Absorption

After oral administration, dapsone is well absorbed from the gastrointestinal tract, with a bioavailibility of more than 86%. Peak serum levels are reached 2-6 h after a single dose is administered. After 8-10 days of therapy at a constant dosage level, the serum level stabilizes and remains at that point unless the dosage is changed. The elimination half-life ranges from 12-30 h, which may be due to the enterohepatic circulation of the drug and the extensive protein binding (Katz 1999, Lang 1979, Zhu and Stiller 2001, Zuidema et al. 1986).

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