Phenytoin is an anticonvulsive drug that plays a pivotal role in the management of convulsive diseases. Because there is evidence for immunomodulating and anti-inflammatory activity of phenytoin, it was also considered a valuable alternative to treat LE. Accordingly, in one study, patients with DLE were treated with phenytoin for an average of 5 months, and cutaneous lesions were evaluated every 4 weeks (Rodriguez-Castellanos et al. 1995). Patients received 100mg of sodium diphenyl-hydantoin by mouth three times daily. In 9 of 10 patients with disseminated DLE, the response was reported to be excellent, and in 1 patient the response was considered to be very good (Callen 1982). Similar results were reported in another study demonstrating that 90% of patients (35 of 39 patients) with DLE significantly improved on treatment with phenytoin. Moreover, the remaining 4 patients (10%) also noted very good resolution of skin lesions. Toxicity was minimal in prevalence and severity. Within a follow-up period of 6-12 months, approximately 33% of patients remained without relapse, whereas approximately 16% relapsed. Follow-up data were not available in the remaining approximately 51% of the patients. Although, the exact mechanism of action of phenytoin in improving DLE is unclear, the promising clinical results may encourage further controlled clinical trials.

Back Pain Revealed

Back Pain Revealed

Tired Having Back Pains All The Time, But You Choose To Ignore It? Every year millions of people see their lives and favorite activities limited by back pain. They forego activities they once loved because of it and in some cases may not even be able to perform their job as well as they once could due to back pain.

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