Subacute Cutaneous Lupus Erythematosus

SCLE occurs in 7%-27% of patients with LE (Cohen and Crosby 1994). Studies have shown that SCLE occurs mostly in white female patients in all age groups. Of patients with SCLE, 60%-81% have positive ANAs when human tissue substrate is used (Callen and Klein 1988). With immunodiffusion techniques, anti-Ro/SSA antibodies have been detected in 40%-100% of patients with SCLE (Lee et al. 1994). Anti-La/SSB antibodies by gel double diffusion have been observed in 12%-42% of patients with SCLE (Johansson-Stephansson et al. 1989). However, higher percentages of anti-La/SSB antibody levels have been seen in several studies outside the United States (Shou-yi et al. 1987). It has been reported that patients with SCLE have anti-ds-DNA at a prevalence of 1.2% (Chelbus et al. 1998).

A false-positive syphilis serologic test result is detected in 17%-33% of patients with SCLE (Sontheimer 1989), and ca. 10%-16% of patients with SCLE have anticar-diolipin antibodies (Fonesca et al. 1992). Rheumatoid factor is present in approximately one third of patients (Sontheimer 1989). Only 10% of patients with SCLE have anti-ds-DNA, anti-SmRNP, or anti-U1RNP antibodies (Sontheimer 1989). Approximately one third of patients with SCLE have antilymphocyte antibodies, and 18%-44% of patients with SCLE are reported to possess antithyroid antibodies (Callen et al. 1986, Konstadoulakis et al. 1993).

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